Ytterbium »
PDB 1c5k-3fty »
3fh8 »
Ytterbium in PDB 3fh8: Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine.
Enzymatic activity of Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine.
All present enzymatic activity of Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine.:
3.3.2.6;
3.3.2.6;
Protein crystallography data
The structure of Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine., PDB code: 3fh8
was solved by
B.Mamat,
D.R.Davies,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.00 / 1.67 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 78.174, 87.357, 99.857, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17.1 / 20.1 |
Other elements in 3fh8:
The structure of Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine. also contains other interesting chemical elements:
| Zinc | (Zn) | 1 atom |
Ytterbium Binding Sites:
The binding sites of Ytterbium atom in the Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine.
(pdb code 3fh8). This binding sites where shown within
5.0 Angstroms radius around Ytterbium atom.
In total 3 binding sites of Ytterbium where determined in the Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine., PDB code: 3fh8:
Jump to Ytterbium binding site number: 1; 2; 3;
In total 3 binding sites of Ytterbium where determined in the Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine., PDB code: 3fh8:
Jump to Ytterbium binding site number: 1; 2; 3;
Ytterbium binding site 1 out of 3 in 3fh8
Go back to
Ytterbium Binding Sites List in 3fh8
Ytterbium binding site 1 out
of 3 in the Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Ytterbium with other atoms in the Yb binding
site number 1 of Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine. within 5.0Å range:
|
Ytterbium binding site 2 out of 3 in 3fh8
Go back to
Ytterbium Binding Sites List in 3fh8
Ytterbium binding site 2 out
of 3 in the Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Ytterbium with other atoms in the Yb binding
site number 2 of Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine. within 5.0Å range:
|
Ytterbium binding site 3 out of 3 in 3fh8
Go back to
Ytterbium Binding Sites List in 3fh8
Ytterbium binding site 3 out
of 3 in the Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Ytterbium with other atoms in the Yb binding
site number 3 of Leukotriene A4 Hydrolase Complexed with Inhibitor 1-[2-(4- Benzylphenoxy)Ethyl]Pyrrolidine. within 5.0Å range:
|
Reference:
V.Sandanayaka,
B.Mamat,
R.K.Mishra,
J.Winger,
M.Krohn,
L.M.Zhou,
M.Keyvan,
L.Enache,
D.Sullins,
E.Onua,
J.Zhang,
G.Halldorsdottir,
H.Sigthorsdottir,
A.Thorlaksdottir,
G.Sigthorsson,
M.Thorsteinnsdottir,
D.R.Davies,
L.J.Stewart,
D.E.Zembower,
T.Andresson,
A.S.Kiselyov,
J.Singh,
M.E.Gurney.
Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy) Phenoxy]Methyl}-1-Pyrrolidinyl]Butanoic Acid (Dg-051) As A Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis. J.Med.Chem. V. 53 573 2010.
ISSN: ISSN 0022-2623
PubMed: 19950900
DOI: 10.1021/JM900838G
Page generated: Sat Oct 12 21:04:52 2024
ISSN: ISSN 0022-2623
PubMed: 19950900
DOI: 10.1021/JM900838G
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
