Ytterbium in PDB 2vj8: Complex of Human Leukotriene A4 Hydrolase with A Hydroxamic Acid Inhibitor

All present enzymatic activity of Complex of Human Leukotriene A4 Hydrolase with A Hydroxamic Acid Inhibitor:
3.3.2.6;

The structure of Complex of Human Leukotriene A4 Hydrolase with A Hydroxamic Acid Inhibitor, PDB code: 2vj8 was solved by M.M.G.M.Thunnissen, B.Andersson, C.-H.Wong, B.Samuelsson, J.Z.Haeggstrom, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.80
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	67.770, 132.470, 83.700, 90.00, 90.00, 90.00
R / Rfree (%)	19.5 / 23.5

The structure of Complex of Human Leukotriene A4 Hydrolase with A Hydroxamic Acid Inhibitor also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Ytterbium atom in the Complex of Human Leukotriene A4 Hydrolase with A Hydroxamic Acid Inhibitor (pdb code 2vj8). This binding sites where shown within 5.0 Angstroms radius around Ytterbium atom.
In total 3 binding sites of Ytterbium where determined in the Complex of Human Leukotriene A4 Hydrolase with A Hydroxamic Acid Inhibitor, PDB code: 2vj8:
Jump to Ytterbium binding site number: 1; 2; 3;

Ytterbium binding site 1 out of 3 in the Complex of Human Leukotriene A4 Hydrolase with A Hydroxamic Acid Inhibitor


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 1 of Complex of Human Leukotriene A4 Hydrolase with A Hydroxamic Acid Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Yb1612 b:18.1 occ:1.00 O A:HOH2456 2.3 18.7 1.0 O A:HOH2460 2.3 12.9 1.0 OD2 A:ASP481 2.3 14.6 1.0 O A:HOH2461 2.3 17.8 1.0 OD1 A:ASP481 2.5 19.3 1.0 CG A:ASP481 2.8 36.7 1.0 OD1 A:ASP482 4.2 21.6 1.0 CB A:ASP481 4.3 21.9 1.0 OD2 A:ASP482 4.4 25.2 1.0 O A:HOH2457 4.5 31.2 1.0 O A:HOH2458 4.5 18.1 1.0 O A:HOH2184 4.6 29.5 1.0 CG A:ASP482 4.6 23.2 1.0 O A:HOH2451 4.7 23.5 1.0 CB A:LYS479 4.9 23.9 1.0

Ytterbium binding site 2 out of 3 in the Complex of Human Leukotriene A4 Hydrolase with A Hydroxamic Acid Inhibitor


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 2 of Complex of Human Leukotriene A4 Hydrolase with A Hydroxamic Acid Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Yb1613 b:24.8 occ:0.60 O A:HOH2097 1.4 14.2 1.0 O A:HOH2096 1.8 32.7 1.0 OE2 A:GLU107 2.3 37.6 1.0 OE1 A:GLU107 2.4 48.9 1.0 CD A:GLU107 2.7 52.6 1.0 O A:HOH2098 2.7 33.4 1.0 YB A:YB1617 3.6 28.5 0.5 CG A:GLU107 4.2 43.5 1.0 O A:HOH2099 4.7 36.3 1.0

Ytterbium binding site 3 out of 3 in the Complex of Human Leukotriene A4 Hydrolase with A Hydroxamic Acid Inhibitor


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 3 of Complex of Human Leukotriene A4 Hydrolase with A Hydroxamic Acid Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Yb1617 b:28.5 occ:0.50 O A:HOH2097 2.4 14.2 1.0 YB A:YB1613 3.6 24.8 0.6 O A:HOH2098 4.5 33.4 1.0 OE2 A:GLU107 4.7 37.6 1.0

M.M.G.M.Thunnissen, B.Andersson, C.-H.Wong, B.Samuelsson, J.Z.Haeggstrom. Crystal Structures of Leukotriene A4 Hydrolase in Complex with Captopril and Two Competitive Tight-Binding Inhibitors Faseb J. V. 16 1648 2002.
ISSN: ISSN 0892-6638
PubMed: 12207002
DOI: 10.1096/FJ.01-1017FJE