Ytterbium in PDB 4mkt: Human Leukotriene A4 Hydrolase in Complex with Pro-Gly-Pro Analogue and 4-(4-Benzylphenyl)Thiazol-2-Amine

All present enzymatic activity of Human Leukotriene A4 Hydrolase in Complex with Pro-Gly-Pro Analogue and 4-(4-Benzylphenyl)Thiazol-2-Amine:
3.3.2.6;

The structure of Human Leukotriene A4 Hydrolase in Complex with Pro-Gly-Pro Analogue and 4-(4-Benzylphenyl)Thiazol-2-Amine, PDB code: 4mkt was solved by A.Stsiapanava, A.Rinaldo-Matthis, J.Z.Haeggstrom, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.79 / 1.62
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	76.809, 87.588, 100.056, 90.00, 90.00, 90.00
R / Rfree (%)	15.6 / 19.3

The structure of Human Leukotriene A4 Hydrolase in Complex with Pro-Gly-Pro Analogue and 4-(4-Benzylphenyl)Thiazol-2-Amine also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Ytterbium atom in the Human Leukotriene A4 Hydrolase in Complex with Pro-Gly-Pro Analogue and 4-(4-Benzylphenyl)Thiazol-2-Amine (pdb code 4mkt). This binding sites where shown within 5.0 Angstroms radius around Ytterbium atom.
In total 2 binding sites of Ytterbium where determined in the Human Leukotriene A4 Hydrolase in Complex with Pro-Gly-Pro Analogue and 4-(4-Benzylphenyl)Thiazol-2-Amine, PDB code: 4mkt:
Jump to Ytterbium binding site number: 1; 2;

Ytterbium binding site 1 out of 2 in the Human Leukotriene A4 Hydrolase in Complex with Pro-Gly-Pro Analogue and 4-(4-Benzylphenyl)Thiazol-2-Amine


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 1 of Human Leukotriene A4 Hydrolase in Complex with Pro-Gly-Pro Analogue and 4-(4-Benzylphenyl)Thiazol-2-Amine within 5.0Å range: probe atom residue distance (Å) B Occ A:Yb704 b:10.4 occ:0.50 O A:HOH967 1.8 19.4 1.0 OXT A:ACY706 2.1 8.2 0.5 OD2 A:ASP47 2.5 17.3 1.0 OD1 A:ASP47 2.5 19.0 1.0 O A:HOH869 2.5 19.6 1.0 O A:ACY706 2.6 9.5 0.5 C A:ACY706 2.7 10.3 0.5 CG A:ASP47 2.8 18.2 1.0 CH3 A:ACY706 4.2 9.2 0.5 CB A:ASP47 4.3 19.0 1.0 O A:HOH1288 4.4 45.6 1.0 OG A:SER95 4.5 20.7 0.6 N A:ASN48 4.6 15.5 1.0 O A:HOH846 4.6 16.6 1.0 O A:HOH978 4.8 23.1 1.0 CB A:ASN48 4.9 16.7 1.0 CA A:ASP47 5.0 19.4 1.0

Ytterbium binding site 2 out of 2 in the Human Leukotriene A4 Hydrolase in Complex with Pro-Gly-Pro Analogue and 4-(4-Benzylphenyl)Thiazol-2-Amine


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 2 of Human Leukotriene A4 Hydrolase in Complex with Pro-Gly-Pro Analogue and 4-(4-Benzylphenyl)Thiazol-2-Amine within 5.0Å range: probe atom residue distance (Å) B Occ A:Yb705 b:26.8 occ:0.50 OD1 A:ASP481 2.0 16.1 1.0 O A:ACY707 2.3 21.7 0.5 OD2 A:ASP481 2.3 16.2 1.0 O A:HOH905 2.3 15.0 1.0 CG A:ASP481 2.4 16.2 1.0 OXT A:ACY707 2.6 21.8 0.5 C A:ACY707 2.8 21.9 0.5 CB A:ASP481 3.9 14.4 1.0 OD2 A:ASP482 4.2 16.6 1.0 OD1 A:ASP482 4.3 18.9 1.0 CH3 A:ACY707 4.3 17.5 0.5 O A:HOH1151 4.4 50.4 1.0 CB A:LYS479 4.5 15.0 0.6 CG A:ASP482 4.6 17.4 1.0 CB A:LYS479 4.6 15.2 0.4 CG A:LYS479 4.7 14.6 0.6 CA A:ASP481 4.8 14.2 1.0 O A:HOH1131 4.8 37.1 1.0 C A:ASP481 5.0 17.0 1.0

A.Stsiapanava, U.Olsson, M.Wan, T.Kleinschmidt, D.Rutishauser, R.A.Zubarev, B.Samuelsson, A.Rinaldo-Matthis, J.Z.Haeggstrom. Binding of Pro-Gly-Pro at the Active Site of Leukotriene A4 Hydrolase/Aminopeptidase and Development of An Epoxide Hydrolase Selective Inhibitor. Proc.Natl.Acad.Sci.Usa V. 111 4227 2014.
ISSN: ISSN 0027-8424
PubMed: 24591641
DOI: 10.1073/PNAS.1402136111