Atomistry » Ytterbium » PDB 3ftz-5i2s » 3fun
Atomistry »
  Ytterbium »
    PDB 3ftz-5i2s »
      3fun »

Ytterbium in PDB 3fun: Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone

Enzymatic activity of Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone

All present enzymatic activity of Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone:
3.3.2.6;

Protein crystallography data

The structure of Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone, PDB code: 3fun was solved by D.R.Davies, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 1.58
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 78.534, 87.142, 99.497, 90.00, 90.00, 90.00
R / Rfree (%) 17.6 / 20.1

Other elements in 3fun:

The structure of Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Ytterbium Binding Sites:

The binding sites of Ytterbium atom in the Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone (pdb code 3fun). This binding sites where shown within 5.0 Angstroms radius around Ytterbium atom.
In total only one binding site of Ytterbium was determined in the Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone, PDB code: 3fun:

Ytterbium binding site 1 out of 1 in 3fun

Go back to Ytterbium Binding Sites List in 3fun
Ytterbium binding site 1 out of 1 in the Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 1 of Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Yb702

b:14.9
occ:1.00
 O A:HOH624 2.2 10.5 1.0
OD2 A:ASP481 2.4 13.7 1.0
OXT A:ACT801 2.4 15.6 1.0
O A:HOH754 2.5 14.2 1.0
O A:ACT801 2.5 13.5 1.0
OD1 A:ASP481 2.6 10.6 1.0
O A:HOH755 2.7 16.4 1.0
CG A:ASP481 2.8 10.0 1.0
C A:ACT801 2.8 15.0 1.0
CH3 A:ACT801 4.3 16.1 1.0
CB A:ASP481 4.4 11.2 1.0
OD2 A:ASP482 4.4 15.9 1.0
OD1 A:ASP482 4.4 15.3 1.0
O A:HOH771 4.6 12.8 1.0
CG A:ASP482 4.7 14.5 1.0
CB A:LYS479 4.8 12.2 1.0

Reference:

D.R.Davies, B.Mamat, O.T.Magnusson, J.Christensen, M.H.Haraldsson, R.Mishra, B.Pease, E.Hansen, J.Singh, D.Zembower, H.Kim, A.S.Kiselyov, A.B.Burgin, M.E.Gurney, L.J.Stewart. Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography. J.Med.Chem. V. 52 4694 2009.
ISSN: ISSN 0022-2623
PubMed: 19618939
DOI: 10.1021/JM900259H
Page generated: Tue Aug 19 18:51:39 2025

Last articles

Zn in 4IDW
Zn in 4IE0
Zn in 4ICQ
Zn in 4IDR
Zn in 4IC3
Zn in 4IC2
Zn in 4IBZ
Zn in 4IBY
Zn in 4IBW
Zn in 4IBV
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy