Ytterbium in PDB 3b7u: Leukotriene A4 Hydrolase Complexed with Kelatorphan

All present enzymatic activity of Leukotriene A4 Hydrolase Complexed with Kelatorphan:
3.3.2.6;

The structure of Leukotriene A4 Hydrolase Complexed with Kelatorphan, PDB code: 3b7u was solved by F.Tholander, J.Haeggstrom, M.Thunnissen, A.Muroya, B.-P.Roques, M.-C.Fournie-Zaluski, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	14.67 / 1.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	77.829, 87.136, 99.191, 90.00, 90.00, 90.00
R / Rfree (%)	17 / 21.7

The structure of Leukotriene A4 Hydrolase Complexed with Kelatorphan also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Ytterbium atom in the Leukotriene A4 Hydrolase Complexed with Kelatorphan (pdb code 3b7u). This binding sites where shown within 5.0 Angstroms radius around Ytterbium atom.
In total 3 binding sites of Ytterbium where determined in the Leukotriene A4 Hydrolase Complexed with Kelatorphan, PDB code: 3b7u:
Jump to Ytterbium binding site number: 1; 2; 3;

Ytterbium binding site 1 out of 3 in the Leukotriene A4 Hydrolase Complexed with Kelatorphan


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 1 of Leukotriene A4 Hydrolase Complexed with Kelatorphan within 5.0Å range: probe atom residue distance (Å) B Occ X:Yb702 b:11.9 occ:1.00 O X:HOH747 2.3 3.4 1.0 OD2 X:ASP481 2.3 7.3 1.0 OXT X:ACY706 2.4 5.7 1.0 O X:HOH771 2.4 6.7 1.0 OD1 X:ASP481 2.5 8.2 1.0 O X:ACY706 2.5 6.8 1.0 C X:ACY706 2.8 6.9 1.0 CG X:ASP481 2.8 11.2 1.0 O X:HOH741 4.2 4.8 1.0 CH3 X:ACY706 4.3 6.6 1.0 CB X:ASP481 4.3 9.1 1.0 OD2 X:ASP482 4.4 11.5 1.0 OD1 X:ASP482 4.4 12.5 1.0 CG X:ASP482 4.8 13.7 1.0 CB X:LYS479 4.8 5.8 1.0 CG X:LYS479 4.8 9.8 1.0

Ytterbium binding site 2 out of 3 in the Leukotriene A4 Hydrolase Complexed with Kelatorphan


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 2 of Leukotriene A4 Hydrolase Complexed with Kelatorphan within 5.0Å range: probe atom residue distance (Å) B Occ X:Yb703 b:22.2 occ:0.25 O X:HOH1085 2.8 36.7 1.0 O X:ASP610 3.5 39.9 1.0 CA X:ASP610 4.0 39.2 1.0 C X:ASP610 4.2 40.0 1.0 N X:ASP610 4.3 36.3 1.0 OD1 X:ASP610 4.6 41.6 1.0

Ytterbium binding site 3 out of 3 in the Leukotriene A4 Hydrolase Complexed with Kelatorphan


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 3 of Leukotriene A4 Hydrolase Complexed with Kelatorphan within 5.0Å range: probe atom residue distance (Å) B Occ X:Yb704 b:18.9 occ:0.25 OD2 X:ASP175 2.1 29.3 1.0 CG X:ASP175 3.3 22.7 1.0 OD1 X:ASP175 3.9 26.2 1.0 CB X:ASP175 4.5 17.3 1.0 CA X:ASP175 4.7 17.1 1.0 O X:ASP175 4.7 20.0 1.0 C X:ASP175 5.0 18.2 1.0

F.Tholander, A.Muroya, B.P.Roques, M.C.Fournie-Zaluski, M.M.Thunnissen, J.Z.Haeggstrom. Structure-Based Dissection of the Active Site Chemistry of Leukotriene A4 Hydrolase: Implications For M1 Aminopeptidases and Inhibitor Design. Chem.Biol. V. 15 920 2008.
ISSN: ISSN 1074-5521
PubMed: 18804029
DOI: 10.1016/J.CHEMBIOL.2008.07.018