Atomistry » Ytterbium » PDB 5l2m-7jww » 7auz
Atomistry »
  Ytterbium »
    PDB 5l2m-7jww »
      7auz »

Ytterbium in PDB 7auz: LTA4 Hydrolase in Complex with Compound LYS006

Enzymatic activity of LTA4 Hydrolase in Complex with Compound LYS006

All present enzymatic activity of LTA4 Hydrolase in Complex with Compound LYS006:
3.3.2.6;

Protein crystallography data

The structure of LTA4 Hydrolase in Complex with Compound LYS006, PDB code: 7auz was solved by H.Srinivas, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.92 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 78.189, 86.7, 98.962, 90, 90, 90
R / Rfree (%) 17.1 / 20.6

Other elements in 7auz:

The structure of LTA4 Hydrolase in Complex with Compound LYS006 also contains other interesting chemical elements:

Fluorine (F) 1 atom
Zinc (Zn) 1 atom
Chlorine (Cl) 1 atom

Ytterbium Binding Sites:

The binding sites of Ytterbium atom in the LTA4 Hydrolase in Complex with Compound LYS006 (pdb code 7auz). This binding sites where shown within 5.0 Angstroms radius around Ytterbium atom.
In total 3 binding sites of Ytterbium where determined in the LTA4 Hydrolase in Complex with Compound LYS006, PDB code: 7auz:
Jump to Ytterbium binding site number: 1; 2; 3;

Ytterbium binding site 1 out of 3 in 7auz

Go back to Ytterbium Binding Sites List in 7auz
Ytterbium binding site 1 out of 3 in the LTA4 Hydrolase in Complex with Compound LYS006


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 1 of LTA4 Hydrolase in Complex with Compound LYS006 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Yb703

b:22.8
occ:1.00
OXT A:ACT702 2.3 17.7 1.0
OD1 A:ASP481 2.5 19.5 1.0
OD2 A:ASP481 2.5 22.1 1.0
O A:ACT702 2.7 20.0 1.0
C A:ACT702 2.8 17.8 1.0
CG A:ASP481 2.8 19.8 1.0
CH3 A:ACT702 4.3 17.4 1.0
CB A:ASP481 4.4 16.3 1.0
OD2 A:ASP482 4.4 28.6 1.0
OD1 A:ASP482 4.4 25.4 1.0
O A:HOH897 4.5 18.0 1.0
CG A:ASP482 4.7 25.7 1.0
O A:HOH1231 4.8 36.7 1.0
CB A:LYS479 4.8 17.7 1.0
CG A:LYS479 4.9 24.9 1.0

Ytterbium binding site 2 out of 3 in 7auz

Go back to Ytterbium Binding Sites List in 7auz
Ytterbium binding site 2 out of 3 in the LTA4 Hydrolase in Complex with Compound LYS006


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 2 of LTA4 Hydrolase in Complex with Compound LYS006 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Yb704

b:35.3
occ:0.26
OD1 A:ASP175 2.4 41.8 1.0
CG A:ASP175 3.6 41.0 1.0
OD2 A:ASP175 4.1 46.9 1.0
CB A:ASP175 4.8 26.0 1.0
CA A:ASP175 4.9 23.9 1.0
O A:ASP175 5.0 30.2 1.0

Ytterbium binding site 3 out of 3 in 7auz

Go back to Ytterbium Binding Sites List in 7auz
Ytterbium binding site 3 out of 3 in the LTA4 Hydrolase in Complex with Compound LYS006


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 3 of LTA4 Hydrolase in Complex with Compound LYS006 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Yb705

b:57.5
occ:1.00
OD1 A:ASP426 2.7 43.5 1.0
O A:HOH946 3.3 47.9 1.0
CG A:ASP426 3.9 42.2 1.0
CA A:ASP426 4.4 20.6 1.0
CB A:ASP426 4.4 23.7 1.0
O A:ASP426 4.6 21.1 1.0
OD2 A:ASP426 4.9 50.1 1.0
CB A:TYR429 4.9 24.1 1.0

Reference:

C.Markert, G.Thoma, H.Srinivas, B.Bollbuck, R.M.Luond, W.Miltz, R.Wal̈Chli, R.Wolf, J.Hinrichs, C.Bergsdorf, K.Azzaoui, C.A.Penno, K.Klein, N.Wack, P.Jag̈Er, F.Hasler, C.Beerli, P.Loetscher, J.Dawson, G.Wieczorek, S.Numao, A.Littlewood-Evans, T.A.Rohn. Discovery of LYS006, A Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase. J.Med.Chem. 2021.
ISSN: ISSN 0022-2623
Page generated: Wed Mar 3 15:46:49 2021

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy