Ytterbium in PDB 5bpp: Structure of Human Leukotriene A4 Hydrolase in Complex with Inhibitor 4AZ

All present enzymatic activity of Structure of Human Leukotriene A4 Hydrolase in Complex with Inhibitor 4AZ:
3.3.2.6;

The structure of Structure of Human Leukotriene A4 Hydrolase in Complex with Inhibitor 4AZ, PDB code: 5bpp was solved by J.Huang, N.N.Dong, Q.Xiao, P.Y.Ou, D.Wu, W.Q.Lu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.59 / 2.03
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	77.983, 87.186, 99.434, 90.00, 90.00, 90.00
R / Rfree (%)	18.1 / 22.4

The structure of Structure of Human Leukotriene A4 Hydrolase in Complex with Inhibitor 4AZ also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Ytterbium atom in the Structure of Human Leukotriene A4 Hydrolase in Complex with Inhibitor 4AZ (pdb code 5bpp). This binding sites where shown within 5.0 Angstroms radius around Ytterbium atom.
In total 3 binding sites of Ytterbium where determined in the Structure of Human Leukotriene A4 Hydrolase in Complex with Inhibitor 4AZ, PDB code: 5bpp:
Jump to Ytterbium binding site number: 1; 2; 3;

Ytterbium binding site 1 out of 3 in the Structure of Human Leukotriene A4 Hydrolase in Complex with Inhibitor 4AZ


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 1 of Structure of Human Leukotriene A4 Hydrolase in Complex with Inhibitor 4AZ within 5.0Å range: probe atom residue distance (Å) B Occ A:Yb702 b:0.8 occ:1.00 OD1 A:ASP175 2.6 39.3 1.0 CG A:ASP175 3.8 36.9 1.0 OD2 A:ASP175 4.3 40.9 1.0 O A:ASP175 4.6 37.5 1.0 CA A:ASP175 4.8 28.1 1.0 CB A:ASP175 4.9 31.6 1.0 C A:ASP175 5.0 31.7 1.0

Ytterbium binding site 2 out of 3 in the Structure of Human Leukotriene A4 Hydrolase in Complex with Inhibitor 4AZ


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 2 of Structure of Human Leukotriene A4 Hydrolase in Complex with Inhibitor 4AZ within 5.0Å range: probe atom residue distance (Å) B Occ A:Yb703 b:0.6 occ:1.00 CG A:GLU182 3.6 55.7 1.0 CB A:GLU182 4.0 47.6 1.0 OD1 A:ASP180 4.1 39.8 1.0 OD2 A:ASP180 4.3 35.0 1.0 CG A:ASP180 4.6 35.9 1.0

Ytterbium binding site 3 out of 3 in the Structure of Human Leukotriene A4 Hydrolase in Complex with Inhibitor 4AZ


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 3 of Structure of Human Leukotriene A4 Hydrolase in Complex with Inhibitor 4AZ within 5.0Å range: probe atom residue distance (Å) B Occ A:Yb704 b:0.4 occ:1.00 OE2 A:GLU590 3.0 66.8 1.0 CD A:GLU590 4.0 56.2 1.0 OE1 A:GLU590 4.5 65.9 1.0 CE1 A:HIS591 4.8 39.2 1.0

Q.Xiao, N.N.Dong, X.Yao, D.Wu, Y.Lu, F.Mao, J.Zhu, J.Li, J.Huang, A.Chen, L.Huang, X.Wang, G.Yang, G.He, Y.Xu, W.Q.Lu. Bufexamac Ameliorates Lps-Induced Acute Lung Injury in Mice By Targeting LTA4H Sci Rep V. 6 25298 2016.
ISSN: ESSN 2045-2322
PubMed: 27126280
DOI: 10.1038/SREP25298