Atomistry » Ytterbium » PDB 3ftz-5i2s » 3fuk
Atomistry »
  Ytterbium »
    PDB 3ftz-5i2s »
      3fuk »

Ytterbium in PDB 3fuk: Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid

Enzymatic activity of Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid

All present enzymatic activity of Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid:
3.3.2.6;

Protein crystallography data

The structure of Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid, PDB code: 3fuk was solved by D.R.Davies, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 1.95
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 78.176, 87.220, 99.899, 90.00, 90.00, 90.00
R / Rfree (%) 19.1 / 23.3

Other elements in 3fuk:

The structure of Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Ytterbium Binding Sites:

The binding sites of Ytterbium atom in the Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid (pdb code 3fuk). This binding sites where shown within 5.0 Angstroms radius around Ytterbium atom.
In total only one binding site of Ytterbium was determined in the Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid, PDB code: 3fuk:

Ytterbium binding site 1 out of 1 in 3fuk

Go back to Ytterbium Binding Sites List in 3fuk
Ytterbium binding site 1 out of 1 in the Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 1 of Leukotriene A4 Hydrolase in Complex with 1-[2-(1H-Indol-5- Yloxy)Ethyl]Piperidine-4-Carboxylic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Yb702

b:25.2
occ:1.00
 O A:HOH768 2.4 20.6 1.0
OD1 A:ASP481 2.4 17.7 1.0
O A:HOH674 2.5 13.2 1.0
OD2 A:ASP481 2.5 21.4 1.0
CG A:ASP481 2.8 23.6 1.0
CB A:ASP481 4.3 23.0 1.0
OD1 A:ASP482 4.4 25.9 1.0
OD2 A:ASP482 4.5 23.6 1.0
O A:HOH787 4.5 36.4 1.0
CG A:ASP482 4.7 24.7 1.0
CB A:LYS479 4.8 20.6 1.0
CG A:LYS479 4.9 23.1 1.0

Reference:

D.R.Davies, B.Mamat, O.T.Magnusson, J.Christensen, M.H.Haraldsson, R.Mishra, B.Pease, E.Hansen, J.Singh, D.Zembower, H.Kim, A.S.Kiselyov, A.B.Burgin, M.E.Gurney, L.J.Stewart. Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography. J.Med.Chem. V. 52 4694 2009.
ISSN: ISSN 0022-2623
PubMed: 19618939
DOI: 10.1021/JM900259H
Page generated: Sat Oct 12 21:09:36 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy