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Ytterbium in PDB 3fu3: Leukotriene A4 Hydrolase in Complex with Fragment 4-(2- Amino-1,3-Thiazol-4-Yl)Phenol

Enzymatic activity of Leukotriene A4 Hydrolase in Complex with Fragment 4-(2- Amino-1,3-Thiazol-4-Yl)Phenol

All present enzymatic activity of Leukotriene A4 Hydrolase in Complex with Fragment 4-(2- Amino-1,3-Thiazol-4-Yl)Phenol:
3.3.2.6;

Protein crystallography data

The structure of Leukotriene A4 Hydrolase in Complex with Fragment 4-(2- Amino-1,3-Thiazol-4-Yl)Phenol, PDB code: 3fu3 was solved by D.R.Davies, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 77.664, 87.313, 98.923, 90.00, 90.00, 90.00
R / Rfree (%) 18.9 / 21.7

Other elements in 3fu3:

The structure of Leukotriene A4 Hydrolase in Complex with Fragment 4-(2- Amino-1,3-Thiazol-4-Yl)Phenol also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Ytterbium Binding Sites:

The binding sites of Ytterbium atom in the Leukotriene A4 Hydrolase in Complex with Fragment 4-(2- Amino-1,3-Thiazol-4-Yl)Phenol (pdb code 3fu3). This binding sites where shown within 5.0 Angstroms radius around Ytterbium atom.
In total only one binding site of Ytterbium was determined in the Leukotriene A4 Hydrolase in Complex with Fragment 4-(2- Amino-1,3-Thiazol-4-Yl)Phenol, PDB code: 3fu3:

Ytterbium binding site 1 out of 1 in 3fu3

Go back to Ytterbium Binding Sites List in 3fu3
Ytterbium binding site 1 out of 1 in the Leukotriene A4 Hydrolase in Complex with Fragment 4-(2- Amino-1,3-Thiazol-4-Yl)Phenol


Mono view


Stereo pair view

A full contact list of Ytterbium with other atoms in the Yb binding site number 1 of Leukotriene A4 Hydrolase in Complex with Fragment 4-(2- Amino-1,3-Thiazol-4-Yl)Phenol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Yb702

b:27.4
occ:1.00
 O A:HOH672 1.6 20.0 1.0
O A:ACT801 2.2 25.8 1.0
OD2 A:ASP481 2.2 25.7 1.0
OD1 A:ASP481 2.4 27.6 1.0
O A:HOH707 2.5 18.5 1.0
CG A:ASP481 2.7 27.4 1.0
OXT A:ACT801 2.7 28.4 1.0
C A:ACT801 2.8 27.2 1.0
CB A:ASP481 4.2 25.9 1.0
CH3 A:ACT801 4.3 26.2 1.0
OD2 A:ASP482 4.4 26.8 1.0
O A:HOH617 4.4 20.7 1.0
OD1 A:ASP482 4.4 28.1 1.0
CB A:LYS479 4.7 24.1 1.0
CG A:ASP482 4.7 28.4 1.0

Reference:

D.R.Davies, B.Mamat, O.T.Magnusson, J.Christensen, M.H.Haraldsson, R.Mishra, B.Pease, E.Hansen, J.Singh, D.Zembower, H.Kim, A.S.Kiselyov, A.B.Burgin, M.E.Gurney, L.J.Stewart. Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography. J.Med.Chem. V. 52 4694 2009.
ISSN: ISSN 0022-2623
PubMed: 19618939
DOI: 10.1021/JM900259H
Page generated: Sat Oct 12 21:07:06 2024

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